Dear @northoftheborder, you should view this video. It is to the point and well worth your time. It is not discussing attempts to find that intersection. It is 40 well-known oncologists looking at 1000 patients and setting very clear lines for intermediate and high-risk PC. It does NOT talk about metastatic cancer. This is cancer confined to the prostate considering 3 risk factors that modify that timing. It also clearly suggests (although doesn’t explain why) going beyond that increase mortality risk.