@19lesterk, I did have some serious muscle spasms when they initially ramped the dosage up during the first week. But I have a lot of back issues to begin with. They continue to check my neuro function at each injection. The BIG negative is that it affected my t-cells. I was all ready for CAR-T but my t-cells could not be modified. My doc knew it could be an issue but I just don't think he realized how quickly it would happen. So that would be my word of caution I guess. If your dad has to go on it, hopefully it doesn't affect the car-t process.