@joaniech2004 I have Myelofibrosis. I had the horrible itching prior to being diagnosed with Myelofibrosis. Unbelievable how stupid every doctor (primary, dermatologist, gastroenterologist, allergist, rheumatologist, infectious disease, etc.) was, in that none even suspected a blood disease or sent me to see a hematologist. Primary laughed at my itching. What an idiot! But, a plastic surgeon friend gave me Xanax, and that annihilated the itching. .25 mg per night and zero itching. Perhaps the itching phase passed on its own at this point. I don’t know. I just know that itching is hell and Xanax stopped in.