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caroledge: psoriasis is a negative in my life. I’m hoping you have a solution or suggestions how to live with it. I have taken Otezla 2x day for 4 years plus clobetatol .05% applied 2x day to assorted psoriasis areas of skin. No matter the psoriasis flares for no known reason to: Large areas as well as small areas appearing on arms, legs, torso, back. Huge plaques as well as smaller ones grow abundantly; then they seem to reduce in size for unknown cause.
I will appreciate all help you can suggest. My internal med doc does not seem to know what else I can do.
Help! dbamos1945
Replies to "caroledge: psoriasis is a negative in my life. I’m hoping you have a solution or suggestions..."
@dbamos1945
I have been living with psoriasis for 66 years. Sometimes it affects only small areas, while at other times it spreads across much of my body. Medications, such as Prednisone, provide temporary relief, but periods of stress often trigger inflammation and cause the condition to flare up again.
Maybe this publication will help your doctor:
Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints
https://www.nature.com/articles/s41590-025-02351-z
and
Ode to Salt: Commentary on “Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity”
https://pmc.ncbi.nlm.nih.gov/articles/PMC8740904/
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@dbamos1945 I took Methotrexate and it cleared my psoriasis. Unfortunately I had to stop it because it is not good for my liver, long term.
Then I was on Stelara which wasn’t as effective, and neither was Skyrizi. Now I am taking Bimzelx injections every eight weeks and that has cleared my skin. Of course, psoriasis is an auto immune condition that cannot be cured, but with the right medication for you (each person reacts differently to any one given treatment) it can be controlled.