@eloise999 Thanks for the info. I'm happy to hear the HU treatment is successful for you with no side affects. Yes, I am wary about the autoimmune part. I have hives and have recently had a suspected drug reaction to the Omalizumab (Xolair) monthly injection that I receive as treatment. My dermatologist has also advised Interferon may induce psoriasis. I agree I will have to just try the drugs and see what happens as we are all different. When you say you take HU at a low dose, may I ask what that dose is? Thanks