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PSA not moving?

Posted by beaquilter @beaquilter, Mar 5 9:56am

Hubby went for another Firmagon shot today and so far since starting treatment a year ago for stage 4, the ADT (Firmagon and Zytiga) and Chemo over the summer, helped to get PSA from almost 300 to where it is now, last month it was 0.19 today it was 0.2! I know it's minuscule! But still it DIDN'T go down....
We expected it to keep going to 0 or nil.
They said it's basically the same as last month and fluctuations can happen in a day, which I guess is true, but I don't like that it didn't go down!
(Still has his prostate)

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beaquilter | @beaquilter | Mar 8 4:44pm
In reply to @northoftheborder "@beaquilter In case it's helpful, the LIBERTAS trial currently underway (for pausing ADT in folk who..." + (show)
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@beaquilter In case it's helpful, the LIBERTAS trial currently underway (for pausing ADT in folk who responded well to doublet therapy using Apalutamide) uses this as their criteria:

"…reached a prostate-specific antigen (PSA) level < 0.2 nanograms/millilitres (ng/mL) after 6 months of treatment with apalutamide and ADT combination therapy…"

Abiraterone (Zytiga) is not _quite_ the same as the -lutamides (though still extremely good, and much less costly), so there's a reasonable chance he would have met this trial's entry criteria for strong responders if he'd been on that regimen, and he pretty much hit the target even on Abiraterone. 💪
https://clinicaltrials.gov/study/NCT05884398

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@northoftheborder
Thanks for the info but he hit 0.2 at almost a year so don't know if he would qualify

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northoftheborder | @northoftheborder | Mar 8 5:41pm
In reply to @beaquilter "@northoftheborder Thanks for the info but he hit 0.2 at almost a year so don't know..." + (show)
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@northoftheborder
Thanks for the info but he hit 0.2 at almost a year so don't know if he would qualify

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@beaquilter Fair enough. I was suggesting that if he managed 0.02 on Abiraterone, he might have managed even lower/faster on a -lutamide, but obviously

- that's just speculation/
- individual results vary/
- etc etc.

Still, it seems like a pretty good response, even if it's not what you'd both hoped for. ❤️

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