I was taking AREDS-2, along with a mulit Vitament, Qunol. All contain Vit E. I had a Blephorplasty and ended up with a Retrobulbar Bleed (severe complication that only 0.5% have with this type of surgury, usually associated with massive trauma to the eye, not during surgury). The culprit was determined to be Vit E. I was advised to stop all my supplements that contain Vit E when I have my next surgery to repair the trauma done to my eye in the first surgery. All FYI...