Hi @kat260 - well since I posted the Pegasys started causing minor heart problems so the doctor switched me to Besremi. Less than a week after my first dose of Besremi I ended up in the Er with horrible AFib that hasn't seemed to let up. Since then I've had every test in the world and they found a clot in my jugular vein. So - doctor said no more Besremi; I guess my body doesn't like the interferons. I'm headed back to Hydroxy which wasn't much of an issue except it didn't do anything to fight my TP53 mutation. In answer to your question - I'm 67 and until last week was considered in extremely good shape as far as exercise, weight and diet. This week I can't even walk up a flight of stairs in my house without triggering my heart. I'm hoping this will all subside the longer away from the Besremi shot I get. I have been told that Pegasys is better at fighting cancer than Hydroxy but I've also seen posts of people who have been on Hydroxy for 15plus years and all was well. I really think it is up to how your body responds. Best wishes to you on the journey. It really is possible to lead a very normal life on these medicines for most people.