What to expect with EVP (Enfortumab Vedotin and Pembrolizumab)?

I had six cycles of treatment with a full response after four. My treatments were done via a port because my veins have become very uncooperative after the previous years chemo (gecitibine and cisplatin). The treatments were very very easy. No nausea or vomiting. It’s my understanding that the side effects vary from person to person, but mine were hair loss, constipation and skin rashes, which were severe at times. The dermatology oncologist who works with my medical oncologist has treated with various creams and says some people have the type of reaction I had, have a mild reaction and some don’t have any at all. I also lost my sense of taste and appetite. My doctor discontinued treatment after six cycles and I’m now on Keytruda (pembro?) only.
Still doing well based on scans and most recent signatura. Good luck with your treatment!

Thank you for your detailed reply. Fingers crossed it is effective.

141emp is blessed. Many other patients develop (severe) neuropathy, appetite los, hair loss and many other difficulties.

EVP is not chemo. EV targets NECTIN4. P is an ICI unmasking PDL1 receptors.

So blessed and grateful! I wasn’t super clear above, I did have significant weight loss too. Truthfully I very much needed to lose that weight but not that way and not that quickly . Quality of life was pretty poor when I couldn’t really eat. My neuropathy is about the same from 2024 chemo (gemcitibine and cisplatin). I was significantly weaker due to the weight loss ( lost alot of muscle ) but on the mend there too thanks to PT and functional strength training. Currently the most annoying thing is the itch from the rash. Onc Dermatologist did a biopsy and says it’s drug induced psoriasis from the Keytruda treating with clobetasol cream. On the positive side , I’m happy to be doing well and not at all sad about how my new clothes fit😊

Thank you for expanding on your journey. New wardrobe never hurts 🙂 Glad you are doing well.

I have now had four rounds of ev/pembro. Itchy hives and rash during the first two rounds, faded with rounds three and four, treated with triamcinolone cream. Loss of taste - can't taste salt very well, other stuff tastes weird, chemical taste on tongue all the time. Dry eyes. Mild nausea, lost as few pounds. Fingertips are going numb. Sometimes a little tired, I nap more often. Could be worse.

Thank you for your reply. I will soon see how my body reacts. Hopefully tumor size will be reduced all other side effects sound manageable.

@davemilisa, When do you start treatment with EVP (enfortumab, vedotin + pembrolizumab)? How are you doing?

Thank you for asking. I have had 1 cycle. The only side effect I have seen is lethargy and some aches and pains. I think the latter is just due to being 60 🙂 but so far so good.