Any concerns if you have MGUS and need joint replacement surgery?

Posted by wzls @wzls, Apr 26, 2025

I have read that joint replacements can raise risk of MM. Has anyone with MGUS had any issues with the surgery?

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Thank you all for the responses and experiences. I have not found a surgeon who is overly concerned about the MGUS but was suggested that when doing the hip the posterior approach may be better than anterior to fully view the bone health and make appropriate adjustments if needed. Being a very active person with many animals the longer recovery is not ideal but may be wiser. In any case, MGUS is always in the back of my mind when thinking about any major surgery. I wish you all the best.

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@wzls best of luck. I hope that you will let us know how this goes for you.

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I had total knee replacement last June and I have SMM. My oncologist told me it would be fine and it was. He said just be sure to tell your surgeon so he won’t be surprised when your bloodwork comes back.. I can finally climb steps again.

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@hsminc
FWIW...I had mine done at the mayo Rochester and can't do their normal sedation because I travel there alone and they want a designated driver with you for sedation. They use fentenol on me and I go through the procedures awake...but calm without issue. I have had two cataract surgeries, two angioplasties, and two carpel tunnel surgeries using this protocol without a problem

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@cousinvinney very interesting. Two
Other problems have showed up - incidentals on a CT scan. Thank god I had the CT scan although it didn’t show an intestinal problem. It showed aneurysms in my renal arteries and possible stones in my bile ducts.
Cataracts are now on the back burner.

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