@paul55 My husband also has MCI was diagnosed in August 2025. I posted above somewhere in this thread as what we were told, the diagnosis for either lequembe or Kinsula has to do with the MRI and Pet Scan findings which determines which treatment they recommend. I was told the Kinsula is an 18-month much stronger dose, why the once a month vs. two treatments in one month. Also, I was told the other day, the lequembe treatments are 36 months. with interval MRI's in between. I do know, from being in the doctor' office every two weeks, with spouses waiting for their spouse getting an infusion, that people are seeing results. One man in particular who has had 22 lequembe infusions, filled out the form in the office on his own, his wife told me the first time he has remembered all the question details. That may sound like a small feat to us, but it's huge for them, where all of us just want to see a difference. It sounds like you and your wife are quite active with trips and schedules that you've done for years. Obviously, some of that, changes with the progression of this disease, as you know. I haven't chosen to travel much while my husband is doing lequembe because of the altitude in planes, etc, and my worries about brain bleeds and swelling. I don't know what I don't know so for right now, I just take it one day at a time. I also know, that whether we do something or not, MCI makes them confused, and I realize that my husband treasures the calm, being in a quiet day to day structure. We've done a few short drive trips, not many....so I'm testing the waters. A few meltdowns from that, probably worse for me than him. Unfortunately, you know, things change for us with this disease. We never know what each day brings, but I do know in talking with my husband......he feels it's worth taking the infusions, to try to slow the progression done. He's done well with the infusions for now. I worry, but I would worry just as much if we weren't doing anything. There's no easy fix here. Just the courage of one day at a time. Clarity to know what to do and when. And God's light to help be our guide through this every day. We are not alone.