I tried Dupixent but it raised my eosinophils to super high levels after three shots (I felt horrible so knew something was wrong). I transitioned to Nucala Dec 2024 and it’s been a miracle drug. Zero eosinophils and no significant signs of CEP inflammation since I started. I also have severe asthma and the Nucala hasn’t controlled it on its own. You can also look at Fasenra. I believe that biologic only requires one shot every 28 days (for CEP you need three shots every 28 days).