sorry you are going through this journey. I am now trying to get pharmaceutical genetic testing of the CYP system to see if there is any mutation/impairment in my transport system - the test is limited on what can be tested - but it looks like the most common transport CYP's are tested.... fingers crossed. No matter how it comes back I will either have confirmation that is the problem or I can cross it off the list of possiblities. If it does come back with an indication of a problem - certain drugs can be eliminated or changed to a different metablizing route, or even increased or reduced for better results. I do have an unknown autoimmune issue - hah, even that is up in the air! Good luck!