Is lymphocytic colitis autoimmune?

This is a good discussion of Lymphocytic colitis. It can be caused from NSAIDs but most doctors believe is has autoimmune origins.
https://my.clevelandclinic.org/health/diseases/24634-lymphocytic-colitis
Have you thought about food allergies?
What antacids have you tried?

Have you tried Pepto-Bismol? That was the first thing my Gastro doctor prescribed for me for LC. It then progressed to a Rx Famotidine.

@annpeters Not as a nightly antacid (it could cause too much constipation if taken in large amounts.) While it helps, high-dosage, long-term use is generally not recommended due to a risk of toxic bismuth buildup in the body. I have terrible GERD. I have a prescription Famotidine for now that I can take at night (when my GERD seems at its worst) and I chew Gaviscon in-between times if I have a heartburn flare-up. Famotidine can cause LC or trigger already existing microscopic colitis, so I'm searching still for something to fight the GERD that will not aggravate my condition.

I ended up with this while taking lisinapril (ace inhibitor). It was wickedly bad! I lost 30 pounds in 6 months - had an colonoscopy which diagnosed the issue. Doctors thought ? So my Allergist said that it might be the lisinapril so my BP doc changed that to an ARB. The colitis immediately stopped and I started healing and then the ARB restarted the reaction within a couple of weeks. I am now on labetalol and my bp is great and so is my intestines. So, it could be a drug that is causing it.

@sickofpasswordsu2 So sorry you had this awful experience. I do know that certain drugs can trigger the onset and it sounds like you've got great docs that discovered what works for you! With me, it could have been autoimmune (since I have an autoimmune thyroid disease, plus an autoimmune skin condition) or NSAIDS, which I took often for aches & pains and also PPIs for GERD. All those drugs could be triggers. There are no real alternatives for the GERD drugs, so I'm stuck there. I take budesonide to control the colitis now and no more NSAIDS. I have flare-ups several times a year.

sorry you are going through this journey. I am now trying to get pharmaceutical genetic testing of the CYP system to see if there is any mutation/impairment in my transport system - the test is limited on what can be tested - but it looks like the most common transport CYP's are tested.... fingers crossed. No matter how it comes back I will either have confirmation that is the problem or I can cross it off the list of possiblities. If it does come back with an indication of a problem - certain drugs can be eliminated or changed to a different metablizing route, or even increased or reduced for better results. I do have an unknown autoimmune issue - hah, even that is up in the air! Good luck!

@sickofpasswordsu2 sorry but could you tell me what CYP is an acronym for ?

Cytochrome P450 tests, also called CYP450 tests, are genotyping tests. Your healthcare professional may use cytochrome P450 tests to help find out how quickly your body uses and gets rid of medicine. How the body uses and gets rid of medicine is called processing or metabolizing. Cytochrome P450 enzymes help the body process medicines. Gene traits passed down in families can cause changes in these enzymes, so medicines affect each person differently.

Pharmacogenomics, also called pharmacogenetics, is the study of how genes affect the body's response to medicine. The CYP450 tests look for gene changes, also called gene variations. Gene changes can affect how well a medicine may work for you. Tests also can show if a specific medicine is likely to cause side effects.

The mayo clinic has a good explanation - this is part of it

@reggiemc

I have taken the same drugs as you and I need up with MC after that.
A new thing my husband and sister pushed was for me to try 4 ounces daily of Kombucha. It’s only been 2 weeks but so far it does seem to help. I had to try a couple flavors as I am sensitive to taste and had to hold my nose. Finally the apple goes down the easies and now I don’t hold my nose.
After all we have been through this is a cheap try.
Have a good day !