Positive Evenity results after 10 months of treatment 🎉

Posted by phxmom @phxmom, Nov 22, 2025

I was shocked when I was diagnosed with osteoporosis at only 53. I've always been active, tennis, yoga, Pilates..but also was always considered "small boned." I think for me it was a combination of genetics, a bout of hyperthyroidism mistaken for hot flashes and menopause that contributed to my diagnosis. My numbers were so shocking for a person my age Evenity was suggested as the best option for me. To be honest I was scared to start treatment , but I am so grateful now that I did. I just got the results of my dexa scan, after 10 months of evenity - a 25.5% improvement in my spine (only slight improvement in my total hip and femoral neck) and I am thrilled!! I still have two more rounds of injections remaining and then I'm not sure what I will go on next to preserve the results - suggestions appreciated.
Here are my before and after:

Region Exam Age BMD T-score BMD Change BMD Change
Date g/cm2 vs Baseline vs Previous
AP Spine (L1-L4)
11/14/2025 54 0.884 -1.5 0.180 (25.5%)* 0.180 (25.5%)*
09/26/2024 53 0.704 -3.1
Total Hip (Left)
11/14/2025 54 0.636 -2.5 0.014 (2.2%) 0.014 (2.2%)
09/26/2024 53 0.623 -2.6
Femoral Neck (Left)
11/14/2025 54 0.657 -1.7 0.024 (3.7%) 0.024 (3.7%)
09/26/2024 53 0.634-1.9= 0.022 g/cm², LSC for Total Hip = 0.027 g/cm², LSC for Femoral Neck = 0.029 g/cm²

Impression: The patient has osteoporosis, based on the Left Total Hip T-score. The BMD for the AP Spine (L1-L4) increased by 25.5% since the last DXA exam. Bone mineral density of the lumbar spine may be elevated by degenerative change.

Discussion: SIGNIFICANT BMD GAIN OBSERVED In an untreated patient, BMD typically declines with age. A lack of decline or gain is usually a sign that treatment is efficacious and fracture risk is reduced. It is important to ask patients whether they are taking their medications and to encourage continued and appropriate compliance with their osteoporosis therapies to reduce fracture risk. It is also important to review their risk factors and encourage appropriate calcium and vitamin D intakes, exercise, fall prevention and other lifestyle measures.
Follow-Up: Consider a repeat BMD exam in 2 years or sooner if medically necessary, to reassess this patient's status.

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

phxmom | @phxmom | Nov 23, 2025

In reply to @dianat "I am holding off on the testosterone for now. Not crazy about those side effects." + (show)

@dianat no side effects except more energy. Maybe because I am on a low dose? I held off on trying it but saw a prominent doctor lecture on how important it is for women (including bone health) and that convinced me. So far so good.

phxmom | @phxmom | Nov 23, 2025

In reply to @naturegirl5 "@phxmom I wrote about Reclast because you had not mentioned if your doctor planned any other..." + (show)

@naturegirl5 haven't had my follow up with my Endo yet. Just got my results. Will let you know what she recommends.

beachesanddreams | @beachesanddreams | Nov 25, 2025

In reply to @phxmom "@beachesanddreams I chose to get the shots in my stomach. The two shots were administered simultaneously..." + (show)

@phxmom How SMART to take the Benadryl before and after. I’m so glad it helped you.

Saw my new doc this morning. She is actually recommending Prolia with a calcium-rich diet and a supplement, plus bone-building exercise. My lumbar score was 3.0 and I’m osteopenic everywhere else, and because I tolerated one Prolia injection well already, she said that’s what she would do for her own mom, which was reassuring.

Still, I hear stories like yours, and wonder if I should do the Evenity for a year (Prolia would take a little longer to build back bone), and see what’s what. She did indicate I could do Evenity if the Prolia doesn’t yield the result she wants to see, so there’s that.

I’m so happy for you and your amazing progress. Definitely something to be thankful for this Thanksgiving!

sherr0 | @sherr0 | Feb 24 5:15pm

Does anyone have experience or results with Evenity?

Justin McClanahan, Moderator | @JustinMcClanahan | Mar 3 1:15pm

In reply to @sherr0 "Does anyone have experience or results with Evenity?" + (show)

Hello @sherr0,

I moved your post and combined it within a discussion titled:

"Positive Evenity results after 10 months of treatment"
- https://connect.mayoclinic.org/discussion/positive-evenity-results-after-10-months-of-treatment

@phxmom started this discussion to focus on their positive results from Evenity. It can sometimes be more difficult to find positive experiences with medications because people tend to only feel strongly about posting the negative reactions while those who have positive experiences tend to move on more easily.

@naturegirl5, @neesie0159, and @kristie2 also posted on Mayo Clinic Connect about having positive results with Evenity. @dianat, mentioned they were about to start Evenity and may wish to return to share how they are currently doing after starting.

@sherr0, Is Evenity a treatment you ar exploring with your provider for osteoporosis?

sherr0 | @sherr0 | Mar 3 1:58pm

In reply to @JustinMcClanahan "Hello @sherr0, I moved your post and combined it within a discussion titled: "Positive Evenity results..." + (show)

@JustinMcClanahan I have had 6 infusions so I am halfway through the protocol. My endo check
S progress in the next couple l le of weeks. So far no side affects other than a little fatigue immediately afterward. Is weight loss a result?

beachesanddreams | @beachesanddreams | Mar 3 5:00pm

In reply to @JustinMcClanahan "Hello @sherr0, I moved your post and combined it within a discussion titled: "Positive Evenity results..." + (show)

@JustinMcClanahan Thank you so much for this. I’m bookmarking for future reference. I start Tymlos tomorrow night. The anticipation anxiety is very hard today, but I’m working to get through it.

You’re so right about negative reviews taking center stage. I try to avoid those and put them out of my frame of mind. I am so happy these folks had positive results with Evenity- and in under a year to boot! That’s incredibly positive news!

Thank you for sharing.

ricksgal | @ricksgal | Mar 4 7:18am

In reply to @JustinMcClanahan "Hello @sherr0, I moved your post and combined it within a discussion titled: "Positive Evenity results..." + (show)

@JustinMcClanahan I have finished a year of Evinity and my bone density results were excellent. Fortunately I did not have any side effects from this medication.

beachesanddreams | @beachesanddreams | Mar 4 12:21pm

In reply to @ricksgal "@JustinMcClanahan I have finished a year of Evinity and my bone density results were excellent. Fortunately..." + (show)

@ricksgal I’m so glad to know this, because I just got a message from my rheumatologist telling me NOT to take that first dose of Tymlos (after a Zoom call with a Tymlos patient educator that took one and a half hours) because I had radiation therapy for breast cancer in 2003.

She mentioned Evenity or Prolia instead.

It took me MONTHS to prepare mentally for Tymlos. I’m at my wit’s end here today, but I’ve read many accounts of women doing well on Evenity. I truly do thank you for your post, and I’m happy for you that you had such excellent gains with no side effects. That’s wonderful! 💃🏻

patwerthman | @patwerthman | Mar 6 7:57am

Great news above! I have had improvement also. And waiting to have a Dexa on same machine later this month. Been on since July and still waiting for insurance to cover. Needing to refute and get documentation from doctor.