I have Sjogren's and Lupus and therefore I have dry eye. I have a wonderful Corneal Specialist that I see at Mass. Eye and Ear in Boston. When I first found dry eye to be a problem she recommended Thera Tears (no preservatives, of course!) As time went by that wasn't enough so twice a year she inserts collagen plugs in my tear ducts both upper and lower. This procedure keeps the moisture that you do have in the eye. After 6 months your body completely absorbs the collagen. Then, as time went by my eyes became dryer so she recommended Serum tears made from my blood serum. There is a company that sends a nurse to your home to take 9 vials of blood and this is shipped to the lab and they send the serum tears in a cooler. I keeps them in my freezer and take out one small vial of serum tears and use them 6 times a day. It is amazing I'm guessing because they are biological!!! Specially made contact lenses are also offered. They cover the whole eye and have liquid in them. I don't know if this will be my next step however, I am extremely pleased with Serum Tears .The only down side is that it costs $700.00 but lasts 6 months, hopefully.