Hi Front, you could be my twin. I just finished two years on Tymlos last week, also with minor gains in the spine and minor losses in the hip, femoral neck, and forearm. I am truly bummed about this; I was hoping for much more given all the hype. I was diligent, didn't miss one day over the two years, and yet here we are.

My endocrinologist, who focuses on osteoporosis treatment, also wants me to go back on Prolia, which I took for a couple of years with no side effects and no problems. I can't take alendronate because of longstanding GERD issues and she doesn't like Reclast. All osteoporosis drugs except the anabolic agents bring with them the risk of osteonecrosis, as I understand it.

I know this forum is very down on Prolia, but it works well for my husband and many others. When I took it previously, I didn't have much in the way of gains, but at least I was stable. The biggest issue is that it's hard to go off it, but at my age my doctor says I can just stay on it forever.

Good luck to you. This disease is a miserable thing to deal with; all the treatments have their drawbacks.