@aunt2jack I’m glad you’re seeing an endocrinologist. That makes sense about you not going on Evenity if you have heart disease.

I’ve gained five pounds on Evenity. I’m glad it wasn’t more even though those five pounds are annoying. I hope they’ll come off once I stop.

I am concerned about the rebound effect if you come off Prolia. Prolia doesn’t suppress the formation of osteoclasts like a bisphosphonate does. The osteoclasts continue to develop but are held in an immature stage of development. Once Prolia is stopped, they rapidly mature and go to work destroying bone. So, you end up with a flood of newly mature osteoclasts all at once.

A bisphosphonate taken after Prolia can help slow down this rebound effect but bottom line is that you have a bunch of new osteoclasts going into action all at once.

What happens if you can’t take a bisphosphonate? Say you develop osteonecrosis of the jaw? Or you have a serious side effect?

All of this is just too much risk for me. A lot can happen in a decade or two. Perhaps if I reach my 80s it might be an option I’d try. But at 64, no way.

That said, people do take Prolia without issue for many years.