@christinecaron hi Christine, I guess I am very fortunate because I am overweight, built like my mother, and have been for a long time. I am relatively sedentary the fact that I have a zero calcium score and my most recent cardiac testing, which was very thorough showed nothing concerning, and I do not take a statin makes me feel that there is way more to the story than just a number. I was not eligible for any clinical trials when I first discovered my high LP little A because I had not had any coronary events. I was told that these drugs would be available around 2025. I don’t know if any are available yet, but I assume they will be extremely costly at least until they can come up with a generic. If you’re concerned and comfortable, I would take the statin if offered. I am just on a lot of other medication’s and have a lot of muscle pain so I went off the statin. Unfortunately, my children have also inherited the elevated LP little A. Because mine was so high the doctor told me that it was likely I got the gene that makes LP little A from both my parents. My mom lived to be 95 with no Cardiac events, and my dad did have a heart attack at around 75. He lived another seven years and did not die from a Cardiac event. My brother, who also has very elevated LP little A had a heart attack at 63. He was not taking his blood pressure medication at the time, but he has been fine for the last 12 years. No further events. Feel free to respond with any other questions.