was taking 5 twice a day cut my self back to 2.5 of the eliquis and my pain in my back,legs, knees and muscle spasms in my bladder are killing me. On 5 my ankles and and legs looked like tree stumps and my feet killed me not as bad on 2.5 just one ankle swells big now. I am so depressed it kills me to watch my grandkids now. when I forget to take a pill like at night our in the morning by late afternoon my ankles are better. I cannot take statins because of the same problems. and yes my cardo does not believe me or maybe not care. getting ready to switch.