@psmnonna thanks so much for the valuable information. You are in the same age range and years of being postmenopausal. I do have some calcification in my arteries though. When I did go to see a hormone doctor, she said there is a risk in the first year of using a low dose estradiol patch (along with progesterone) of some plague dislodging and causing a stroke. That scared the daylights out of me, so I didn’t move forward. She was unable to give me a percent risk!