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← Return to Hormone therapy patch
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Prostate Cancer | Last Active: Feb 23 8:11pm | Replies (19)
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@overage
I missed answering one part of this question.
When someone becomes castrate resistant, they are given an ARPI. The patch or ADT they are on would be continued because not all of the cells are castrate resistant. Usually people go on Zytiga first, Unless they have heart issues in which case a lutamide Is much safer.
I became castrate resistant six years ago and my oncologist added Biclutamide to my drugs, it didn’t work well, keeping my PSA down so after 14 months, I was switched to Zytiga. It kept my PSA low, but not undetectable.
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@jeffmarc I raised the question because of a notice in the book Androgen Deprivation Therapy, Third Edition, by Richard J. Wassersug et.al. On page 24 there is this note on the use of estradiol in the event of castration resistance.
"There is also a concern that, with castration-resistant prostate cancer
(CRPC), there can be a change in the hormone receptors on the cancer cells. In that situation, estrogens, which may help patients in managing ADT side
effects, could start to stimulate cancer cell growth. There is not much research on this, but as a cautionary note, it may be best to stop using trans-dermal estradiol
if there is indication that standard ADT can no longer control the cancer."
Perhaps you might inquire with those you know that are using Estradiol on what thy know about what is being done in the PATCH trial with the castration resistant patients.
I asked my oncologist once for estradiol as an add back but received an outright refusal. If I am faced with the possibility of lifetime ADT I would prefer estradiol, but I don't want to be using something that can fuel the cancer.