@gajokos Sure. I’m working from memory, but I would say I had zero symptoms for about a year and half, and then the night sweats and abdominal pain and bone pain in my feet and burning nerve endings in my toes and anemia, and 50 pounds of weight loss came. But, then I was diagnosed with ECD and given the targeted med (not chemo), and all the symptoms went bye-bye. Not sure what symptoms I ever had that would be solely or directly attributable to the myelofibrosis. Probably my slightly enlarged spleen!