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Smoldering Multiple Myeloma (SMM). Questions and Answers
Blood Cancers & Disorders | Last Active: Mar 22 11:35am | Replies (91)Comment receiving replies
I am new to all this. Diagnosed with SMM August 2025; I was 65 then, healthy adult. I don’t have my numbers at my finger tips but I am high risk (based on one of the two charts used to gauge results). My oncologist is starting me next month on Darzalex which was just approved in December 2025 for high risk SMM. Does anyone else have any experience with this new med? It’s given subcutaneously. Thanks.
Replies to "I am new to all this. Diagnosed with SMM August 2025; I was 65 then, healthy..."
@hlwd7
May I ask what your score was for high risk? I am worried about me being high risk now with risky mutations as well.
Thank you
Mascot
@hlwd7
Diagnosed with MM in Sept. 2023. Have had 30 sessions with Darzalex. Also am on lenalidomide; 21 days on, 7 days off. My "numbers" in 9/2023 were in the upper 1200's, now they are in the low 200's. My oncologist is very satisfied with the progress. I have no pains related to MM or any side affects of any consequence. Treatment and meds are very, very expensive. I hope you have as good insurance as I have. Also, I am 83 years old.
Good luck,
Jerry
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@hlwd7 hello, I am still categorized as MGUS and have no experience with Darzalex, but I want to welcome you to Mayo Clinic Connect, and I hope that there are members who will jump on this thread and answer your questions.
I hope that you will share your personal experience with us if you feel comfortable doing that once you start taking the medication.