Has anyone ever been on Duloxetine (Cymbalta) for nerve pain?

Those drugs don't repair nerves missing MYELIN.
That's the insulating fat that coats them like plastic on wires. Vitamin B12 makes new myelin. Older people need B12 supplement because stomach has less acid. Alcohol numbs intestine villi preventing absorption. Good luck.

@emo
Wise decision. I started Cymbalta 16 years ago to treat nerve pain and I am still on it because of the impossibility to wean off of it, for me at least. The side effects when trying to quit were too much for me to tolerate and I know of many others who have not been able to wean off of it. In the US they have made them put a black box warning on the packaging, I guess. There have been class action law suits against the drug manufacturer but I'm in Canada where nothing has happened, no warnings, no lawsuits, nothing.

I did try it a few years ago. Certainly was one of those people who had bad reactions to it. It made me nauseous and dizzy. On advice of my doctor and pharmacist I “gave it a try for a couple of weeks”. It did not really lessen my pain but it did make me feel awful for two weeks. I was never so glad to get off of a medication.
However works wonders for some people, I just wasn’t one of them.

@nogoodgolfnut Yikes, thanks for sharing, and I'm sorry that happened, or I guess is still happening if you weren't able to wean off it. It's not you; it's the medication. As it happens, my rheumatolgist brought up Cymbalta as an option again about a month ago because some of my pain has been progressing. Celebrex is effective, and I was taking it sparingly, but I've had to take it more often, which isn't great because it's an NSAID and I only have one kidney. But I'm still nervous about Cymbalta even though I know it's very effective for some people.

@emo Hi, Ive been on Cymbalta about 3 months and it helped my neuropathic pain a great deal. I was skeptical but it relieved a lot of pain from L5 S1 Spondylisthesis post RFA 12/3/25. Gabapentin made me an emotional wreck, Im allergic.
However now, I'm still limping, doc took an X-ray of my hips and now see my left hip is pretty much bone on bone. Back issue resolved now this.

I was on cymbalta for 6 years for nerve pain and found it helpful. One year ago I gradually weaned off it to try low dose naltexone. I have added 300 mg gabapentin at bedtime and have been miserable recently. Thinking I may need to go back on cymbalta to find relief. Everyone in the EDS community is raving about LDN for pain relief but it hasn't been the magic bullet I'd hoped for!

@catbunting
What is LDN? I've taken Duloxotine for several years, 60 mg. Cannot take 90 mg, it caused some weird problems. Gabapentin screwd up my vision & no signifant pain relief. Had trouble getting 60 mg Duloxotine. Pharmacies were not receiving their orders. Finally found some but I did have some withdrawal.

@chatnoirkc LDN is short hand for Low Dose Naltexone. It's an old drug that is used in 50 to 150mg doses with folks trying to stop drinking. The 1mg to 12 mg dosing is used for pain management and brain fog in MS, hEDS, fibro and nerve pain. The typical low dose is 4.5mg daily. The low dose comes from compounding pharmacy. If you Google LDN you'll find a wealth of research and the complete explanation of how it works to reduce pain and improve quality of life.

I have been on 60mg for years for chronic pain. I have had no problem with it. And I find it does help.

@pen55
Same for me. On it for quite awhile and it helps and no problems with it.