I really appreciate this line of discussion, especially comments by @handera. With a Decipher score of 0.92 putting me in the 98 percentile for risk, so making me very anxious. I have tried to engage my oncologists and even a distinguished research professor at Johns Hopkins Medicine. None could provider any insights. Understandably, the mountain of molecular biology information provided by Vercyte in the Decipher GRID report is way, way beyond the routine standard of care for prostate cancer. Being a PhD biochemist, I have tried myself to learn more about the aberrant genes in my prostate specimens. Of the 60 genes/ expression signatures listed in my GRID report, 19 are listed as of high risk. However, I have to continually remind myself that these results are all only statistical associations. The analyses are not correlations, much less suggesting any insights on differential responses toward therapy and outcomes. Fortunately, my RT and ADT have driven my PSA to undetectable, which has helped my anxiety.
Can any of you suggest clinical researchers anywhere who are engaged with Veracyte to more deeply understand their data? I would really appreciate any recommendations. Thanks again.