Moxifloxin- anyone tried this?

@westscottkm3040 I'm curious- are they doing drug sensitivity testing to determine which antibiotics the bug responds to?

They have. New to the clofazimine. Going to give that one more month. And then add the new one.

I was on Moxi plus Siturro(sp?) plus inhaled Amikacin in 2024 for Simiae that popped up after a Bronch with two alveolar washes. I could not tolerate the Moxi. I could barely walk 50 feet. It’s odd since I have been on Floxi before with zero side effects. You also have to be VERY CAREFUL with Moxi due to tendon issues. Good Luck.

Thanks. Waiting for ct to decide. On 4 things now. He would add a low dose to all.
I did the inhaled amakacin. Had a bunch of issues so stopped it. Nothing seems to really be working this round.

Hello all, this is a very much needed thread, sharing about results with standard treatment and adds on. Thank you very much, good luck and fortitude.

Agreed. I’d rather hear about side effects from someone who has actually tried it. So many drugs out there. Maybe one will help for someone and we can learn from others.

To Wescottk--

I am in nearly the exactly same boat as you. I've been on the Big 3 for a long time, they added clofazimine, and I was on inhaled amikacin for about a year.

They think I have several strains of MAC. After a year on amikacin, they said I was "resistant" to it, but they think one strain may not be. I am not having trouble with clofazimine, but it hasn't helped as much as I had hoped. Same with amikacin (slight hearing loss in upper frequencies).

Now they want to try moxifloxacin.

I read that moxifloxacin is about 29% effective for difficult-to-treat MAC. Beyond issues for the tendons (Achilles, hands, etc.), it may have quite a few other side effects (from what I've read). I'm not a doctor, so I'm just passing this information garnered from online sites along so others can do more research or report their actual experience with it.
1) It can cause neuropathy, which is nerve damage that results in numbness and tingling (hands and feet?)
2) It can affect the CNS, resulting in dizziness, headaches, insomnia, confusion.
3) It can affect the QT interval of heart (though this is monitored carefully with ecg screenings)
4) It can cause mental health issues, including anxiety and hallucinations.
5) If you have heart issues, it can elevate the risk for aortic aneurysm.
If anyone has taken it, how long? What was your experience?

Best regards to all.
Mokie

@sueinmn

Thank you for that Miss Sue. In my case, I have been told I was resistant to several of my medications. Later, they started to think multiple strains of MAC were involved, and so you're so right to ask about that, if I'm following you. For example, amikacin may not be treating one strain, but IS treating another strain.
Some of this is confusing to me!
Mokie

How are you feeling while on the big 3? I never thought that my NTM would return. Good for you being on treatment for a 3rd time. I am trying to avoid going on the antibiotics for the 2nd time. It took me about a year to get the side effects out of my system. Then MAC returned. I could not tolerate the meds very well but I stuck with it. Daily meds are tough on your system. I was on moxi had side effects and I was nervous I still get unusual feelings in my tendons. As long as you are monitored it should be fine. Everyone is different some people experience very few side effects. Good luck

Thank you all for your feedback. I’ve been doing ok on the 4 meds so far. Been 2 months since added the clofazimine. Will look at the moxi to add in April if sputum still coming back pos then. Hoping it will start to be negative so can just stay on this for a bit longer and then be done with meds for a few years till the Mac comes back again.