Yes! My Nurse Practitioner gave me a prescription for 150mg of it. I took 2 pills at night before bed. It worked! Then after the prescription ran out, my Primary Doctor tried to lower my dosage to the 75mg pills. They were useless! He would not renew the 150s! Thanks a lot. Eventually, the NP renewed the inital prescrip of 150s. She had no problem with renewing it. Go figure.