Welcome Steve @stevenh31, It's good to hear that some of your side effects have lessened over time. There are some that seem to hang on and are with us for the long haul. The drugs can be quite effective but harsh. I take a different targeted therapy, alectinib for ALK positive stage 4 lung cancer.

Here's a link to a recent discussion about overcoming weight loss that may be helpful:
https://connect.mayoclinic.org/discussion/weight-loss-from-stage-4-lung-cnacer/
Interesting, your team is looking at adding chemo to the Tagrisso? Do you know yet what type of chemo you may be given?