@daisy17 You have found some very interesting info! That's the first time I've read about study participants starting MK-4 at a low dosage and then increasing it to the full 45 mg. We rarely see studies comparing different dosages. I am curious to know the Japanese Ministry of Health's response to this study. I would assume it has studied the MK-4 dosage over longer periods of time than this study. Still, it's an intriguing study.

I used to take both MK4 and MK7 but stopped taking both when I was diagnosed with afib and started Eliquis, and that was followed by a breast cancer diagnosis. I'm still on Eliquis but had a heart ablation in September. When I asked my electrophysiolgoist if I could resume MK-4, he didn't object.

My plan is to start MK4 but not MK7 which is sometimes linked to heart palpitations. I still need to get the okay from my cardiologist who specializes in cancer to be sure she's also okay with resuming Mk-4. She may tell me I can' take it while taking Eliquis. Have no idea.

So many doctors! It's a challenge juggling all the contraindications when you have multiple issues and medications.

As to your last question, though, yes...many of us wonder why more doctors are not aware of this Japanese approach to osteoporosis. It seems to fit the bill of "do not harm" better than many of the osteoporosis drugs they prescribe.