@prarysky Are you going to start taking the higher (45mg) dose of Vitamin K or MK-4?

I found this from AI Assist: "In Japan, high doses of MK-4 (menaquinone-4), a form of vitamin K2, have been prescribed for decades to treat osteoporosis, showing significant improvements in bone density and reduced fracture risk. Studies indicate that doses around 45 mg daily can effectively help build new bone and slow bone loss."

I also found this: ""MK4 (45 mg/day, given in divided doses and not all at once) has been so well researched that since 1995 it’s been approved by the Japanese Ministry of Health for the treatment of osteoporosis and bone pain caused by osteoporosis". I believe the divided dose is because the vitamin has a short half-life. I also found this review: "The only other bone therapy I find acceptable is vitamin K2 (MK4) at 45 mg/day (15 mg taken three times per day). MK4 at this dosage is given by prescription in Japan and other Asian countries for osteoporosis."

Attached is a link to one study I found. The dosages were: "Participants took low-dose MK-4 (0.5 mg) for 3 weeks (until the second visit), then medium-dose MK-4 (5 mg) for 3 weeks (until the third visit), then high-dose MK-4 (45 mg) for 3 weeks." Findings: " Compared to 5 mg/day, there was no additional benefit of 45 mg/day. There were no major side effects of MK-4 supplementation. In postmenopausal women with osteoporotic fractures, supplementation with either 5 or 45 mg/day of MK-4." So this study found 5mg/ adequate. https://pubmed.ncbi.nlm.nih.gov/30816822/

Another interesting articles: https://betterbones.com/bone-health-basics/vitamin-k2-mk7-vs-mk4/

This one says: "Low-dose (1.5-mg daily) vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women...without any substantial adverse effects." https://pubmed.ncbi.nlm.nih.gov/23702931/

I need to do some more research on this. I wonder why this isn't recommended in the U.S.?