Yes, a couple of months after going off Prednisone, I started feeling achy and stiff, particularly in one knee. It was like Prednisone had made me feel young again, and now the aging process was reversing and I feel older than before I got PMR. Well, I AM older. The rheumatologist wanted to put me back on Prednisone, but I resisted. I'll give it a year, I thought. After a year, I've gotten slammed with a twisted bowel (cecal volvulus) which required emergency surgery and a long recovery. The doctors don't know why it happens and I don't think it is related to PMR, but that has knocked me off my horse and made me feel even older. So that may have hijacked my experiment. I do think there is a price to be paid for the benefits of Prednisone. I would not have done anything differently, but there is a price to be paid.