Pancreatic Cancer Group: Introduce yourself and connect with others

@lhlawrence
I'm an 87 year old man, diagnosed in Feb. 2025 with adenocarcinoma in head of pancreas, non-resectable. I've been on chemo, gemcitabine and abraxane, since March, every 2 weeks, so far no metastasis. My surgical guy, Mark Bloomston, with Lee Health in southwest Florida, introduced me to two potential procedures for shrinkage of the tumor: nanoknife and histotripsy. The latter is non invasive, using high energy ultra sound to generate gas bubbles in the tumor that burst, destroying the tumor in the process. It's new for the pancreas, has been approved for use in the liver by the FCC. I had the histotripsy procedure done in December, as an outpatient, recovery a piece of cake, and significant impact on the tumor. Final results await the next scan, but Bloomston very pleased. Your doctors should be aware of these options, nanoknife has been around for a while. Histotripsy for the pancreas is new and wasn't covered by my insurance. Could be a problem. I've learned a lot from ChatGPT, recommend it as a surrogate doctor for general advice and options for discussion with the real gdoctors. Hope this helps.

@joealp1
Thank you for letting the forum know about histotripsy for pancreas. I had it done on my liver July 2025 and still have a "clean liver". Worked better than the MRI radiation where the effect only lasted 5 months before lesions came back.

@lhlawrence
I'm an 87 year old man, diagnosed in Feb. 2025 with adenocarcinoma in head of pancreas, non-resectable. I've been on chemo, gemcitabine and abraxane, since March, every 2 weeks, so far no metastasis. My surgical guy, Mark Bloomston, with Lee Health in southwest Florida, introduced me to two potential procedures for shrinkage of the tumor: nanoknife and histotripsy. The latter is non invasive, using high energy ultra sound to generate gas bubbles in the tumor that burst, destroying the tumor in the process. It's new for the pancreas, has been approved for use in the liver by the FCC. I had the histotripsy procedure done in December, as an outpatient, recovery a piece of cake, and significant impact on the tumor. Final results await the next scan, but Bloomston very pleased. Your doctors should be aware of these options, nanoknife has been around for a while. Histotripsy for the pancreas is new and wasn't covered by my insurance. Could be a problem. I've learned a lot from ChatGPT, recommend it as a surrogate doctor for general advice and options for discussion with the real gdoctors. Hope this helps.

@joealp1
I just read that histotripsy for the pancreas is not available outside clinical trials. Is that true? Did you have it as part of a clinical trial? Do you mind saying where you had it?
Can you give details on “significant impact on the tumor” such as percentage reduction or went from x cm to y cm? Also, how long was the actual procedure (anesthesia time)? Thank you for any additional info.

@joealp1 You had histotripsy on your pancreas? That's awesome. Last I read, it was still in trial. Please keep us posted on your experiences. You are the first person that I met that had it done on their pancreas. @mnewland99 is my first person that experienced liver histotripsy.

@joealp1
Thank you for letting the forum know about histotripsy for pancreas. I had it done on my liver July 2025 and still have a "clean liver". Worked better than the MRI radiation where the effect only lasted 5 months before lesions came back.

@californiazebra
My procedure was done "off label", in other words, not covered by insurance. Histotripsy for the pancreas is in a clinical trial in Barcelona, but it's a procedure that can be performed, just needs a surgeon trained in the procedure and with access to the equipment. My surgical oncologist is Dr. Mark Bloomston, with Lee Health, 239-343-7400. He's in Ft. Myers, FL. By his estimate, the tumor was shrunk by about 50%, and it's possible that what's left is dead.
The procedure took a little over an hour in the operating room. My tumor was large, 6.9 x 4.8 x 4.2 cm. Doc had to reposition the device for three separate applications; normally, it's only a single set up and the time in the operating room is closer to 45 minutes. Hardest part was the prep, much like prepping for a colonoscopy.
Hope this answers your questions.

@joealp1
Very helpful. Thank you for your response. Yes, that is a large tumor. I’ve been following histotripsy for the liver and love the idea. I’m hoping it will be approved for the pancreas and other organs sooner rather than later. Great that you haven’t had any ill effects from it. Love how quick it was especially given other pancreatic surgeries are so long and brutal. I pray you’ve seen the last of your cancer. 🙏

@lhlawrence
I'm an 87 year old man, diagnosed in Feb. 2025 with adenocarcinoma in head of pancreas, non-resectable. I've been on chemo, gemcitabine and abraxane, since March, every 2 weeks, so far no metastasis. My surgical guy, Mark Bloomston, with Lee Health in southwest Florida, introduced me to two potential procedures for shrinkage of the tumor: nanoknife and histotripsy. The latter is non invasive, using high energy ultra sound to generate gas bubbles in the tumor that burst, destroying the tumor in the process. It's new for the pancreas, has been approved for use in the liver by the FCC. I had the histotripsy procedure done in December, as an outpatient, recovery a piece of cake, and significant impact on the tumor. Final results await the next scan, but Bloomston very pleased. Your doctors should be aware of these options, nanoknife has been around for a while. Histotripsy for the pancreas is new and wasn't covered by my insurance. Could be a problem. I've learned a lot from ChatGPT, recommend it as a surrogate doctor for general advice and options for discussion with the real gdoctors. Hope this helps.

@tomrennie
Histotripsy for the pancreas IS still in trial, I believe trials are necessary to amass data for the FDA to eventually allow insurance coverage. Meanwhile, the procedure is available, just off label. Means you have to pay. It's safe, and it does what it advertises--reduces size of/kills the tumor it addresses. I've had no ill after effects. Based on post treatment CT and PET scans, and after 9 months of chemo, my doctors have paused chemo, waiting to see what happens next. I'm looking forward to a few months of getting back closer to pre-treatment form.