@toste
I was also diagnosed with myelofibrosis and the JAK2 mutation about a year ago. I had extensive radiation for breast cancer in 2003 and started seeing issues with my platelet count a few years later. I don't know for sure that radiation was the cause, but it is a risk factor. I have not experienced issues with circulation. I try to take walks or go on the treadmill most days. The worst symptoms for me are extreme fatigue and itchy skin. The Jakafi medication has helped reduce the itchy skin issue.