@kathleen1314 Thank you very much. I am four months post-total hysterectomy. For a few weeks, Imvexxy + compounded Estradiol cream were sufficient, just as it was pre-hysterectomy. Then two months ago I tried Intrarosa for five weeks. I had a honeymoon period of three weeks with it: my libido mostly returned and I wasn't dry. Then I became irritable, hungry at 2am then my labia majora and minora turned red as did the entrance to my vagina. I tried rubbing on DHEA cream externally but it irritated my skin even more. I'm pretty sure I tried Imvexxy again but I was too far gone with a glowing red crotch. Shortly thereafter, I had a minor operation requiring Fluconzaole and an antibiotic. I ended up at my gyn's office. My irritated, thin skin developed a yeast infection. I'm six days into Terconazole along with topical Clotrimazole+Betamethasone. I gave in and inserted a Vagifem this afternoon thinking I was done with Terconazole but I realized I only have one night left so I think it'll be ok. My bladder is so sore without estrogen.

After all of this is done, I'm going to try Vagifem for as long as my delicate skin could possibly gain something from it then try going back to Imvexxy and using a limited amount of Estradiol cream externally.

I was told about the Estring. Are you familiar with it?

Sorry for the long post, but the GSM has been hell.