First chemo - carboplatin/taxol - what to expect - side effects?

Posted by pretzelnin @pretzelnin, Jan 9, 2023

Hello, I was diagnosed with Stage 3cG3 Uterine Papillary Serous Carcinoma 11/11 also positive in ovaries per pathology report after TAH-BSO on 12/21. Chemo on Carboplatin/Taxol recommended for 6 cycles 1x/3 wks for 18 wks. First chemo scheduled Friday 1/13. Apprehensive of side effects specially of neuropathy. Do side effects happen right away? During session? and for how long? Days 1-4, 2-6? Will youbstillbhave side effects on 2nd-3rd week? NP recommended to wear cooling gloves and socks to guard against neuropathy - has anyone tried them and have positive results?

Has anyone declined carboplatin/Taxol and went on a different regimen instead?

Appreciate all your replies and support.
Maria

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My first four days after first infusion were tough. Please be kind to yourself. I was very light headed on the morning of day 4 and thought I could just muscle through it. Instead, I passed out and fractured my cheekbone! All other cycles went without much incident or drama. Lots of foot neuropathy that I’m still dealing with two months after last infusion. Exercise throughout all of the cycles is really important. Even just a daily 30 minute walk. Wishing you all the best. Hugs

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As our responses show, we are all so different! You will have to find what works for you. One low-cost thing that seemed to help me with nausea was the elastic wristbands people wear on a cruise to help with seasickness. They touch nausea pressure points and seemed to make a big difference for me. You can get them off Amazon or at any CVS or similar drugstore. I wore one, but I understand they work even better with two wristbands (I think they come in sets). Hugs!

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Carboplantin with paxclitaxel was my cause for peripheral neuropathy. It was for me, and after two years I still have it. Initially it started with strange shooting pain in my legs, and this sensation travelled up and down, side-to-side quite rapidly and randomly. I took Gabapentin for this and it helped. I now get cramping in lower legs and feet. Gabapentin doesn't address cramping, as far as I have read. Was told to take Magnesium bisglycinate 200-400 mg. at night. Helps somewhat, although I don't take it regularly. Walking and foot rotation and toe point helps a bit, if nothing else but to get the blood circulation. I also have it in my finger tips.
I did not wear cooling gloves or boots, and I've read that these have helped some other patients. The medical jury is still out on the effectiveness.

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Profile picture for lizziegil @lizziegil

Hi- I just began my chemo on 1/6/26, carboplatin and taxol every 3 weeks for 6 cycles, 18 weeks. I have been on Steeroids and have felt pretty well, probably overdoing it. Last night my legs, knees, calves all started aching pretty severely, hard to sleep. I’ve tried ice, Tylenol, Advil etc. From reading this it does sound like a typical reaction. Does anyone have any suggestions or experience with doing any sort of fast or diet to help with the side effects?
I know it’s important to eat and hydrate but if I could make changes to avoid this discomfort I’d be willing to.
Thanks for sharing your experiences and insights. It makes this experience less overwhelming when you realize you are not alone.

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@lizziegil I was diagnosed with serous papillary carcinoma May 2017- had a second opinion at Moffatt regarding treatment plan. Had same chemo as you and number. Then 3 Brachytherapy sessions for the vaginal cuff. The day after chemo treratment I was ok- days 2-3 terrible could not get out of bed but never nauseous just bad migraines. I hardly told anybody what I had- I wore gorgeous wigs (people wanted to know where I got my hair colored!) I looked great and I had no one living with me. I want to tell you the most important thing I did was to prevent neuropathy in the feet and hands is to ICE ICE ICE them while getting the chemo- have the staff bring tons of ice - you bring the plastic bowl and soak your feet the duration of receiving the chemo treatment. My hands I submerged in ice water- Ice packs would be ok as well. It is a pain to do but let me tell you I have NO signs of neuropathy maybe a tingle in my toes periodically whereas others have suffered greatly. I also had low level laser done to my feet once a week and got foot massages. This whole situation is truly mind over matter. I truly wish you the best. This too shall pass.

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Profile picture for cookercooker @cookercooker

Carboplantin with paxclitaxel was my cause for peripheral neuropathy. It was for me, and after two years I still have it. Initially it started with strange shooting pain in my legs, and this sensation travelled up and down, side-to-side quite rapidly and randomly. I took Gabapentin for this and it helped. I now get cramping in lower legs and feet. Gabapentin doesn't address cramping, as far as I have read. Was told to take Magnesium bisglycinate 200-400 mg. at night. Helps somewhat, although I don't take it regularly. Walking and foot rotation and toe point helps a bit, if nothing else but to get the blood circulation. I also have it in my finger tips.
I did not wear cooling gloves or boots, and I've read that these have helped some other patients. The medical jury is still out on the effectiveness.

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@cookercooker I suffer from lymphedma in my legs from the hysterctomy and brachytherapy. Very upset about this and I have venous insufficiency. Looking into surgery and treatment-I get lymphedema treatment and wear compression hose but not working great.

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Profile picture for cookercooker @cookercooker

Carboplantin with paxclitaxel was my cause for peripheral neuropathy. It was for me, and after two years I still have it. Initially it started with strange shooting pain in my legs, and this sensation travelled up and down, side-to-side quite rapidly and randomly. I took Gabapentin for this and it helped. I now get cramping in lower legs and feet. Gabapentin doesn't address cramping, as far as I have read. Was told to take Magnesium bisglycinate 200-400 mg. at night. Helps somewhat, although I don't take it regularly. Walking and foot rotation and toe point helps a bit, if nothing else but to get the blood circulation. I also have it in my finger tips.
I did not wear cooling gloves or boots, and I've read that these have helped some other patients. The medical jury is still out on the effectiveness.

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@cookercooker Please read my post regarding the cooling.

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Please read my post below. I also took alpha lipoic acid- but most importantly actual ICING throughout the administration of the treatment. I do not and have not suffered from any neuropathy- just lymphedema from hysterctomy and brachytherapy. I had exactly what you had in May 2017. Started with salmon colored staining.

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Profile picture for bocabird @bocabird

@cookercooker I suffer from lymphedma in my legs from the hysterctomy and brachytherapy. Very upset about this and I have venous insufficiency. Looking into surgery and treatment-I get lymphedema treatment and wear compression hose but not working great.

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@bocabird
Did you have a lymphectomy?

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Profile picture for bocabird @bocabird

Please read my post below. I also took alpha lipoic acid- but most importantly actual ICING throughout the administration of the treatment. I do not and have not suffered from any neuropathy- just lymphedema from hysterctomy and brachytherapy. I had exactly what you had in May 2017. Started with salmon colored staining.

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@bocabird
I didn't take any supplements. Did you receive paclitaxel?

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No supplements besides magnesium and vitamin d, I am using the Dixie gloves/ socks during my chemo

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