Recurrent UTIs After Hysterectomy: When antibiotics don't work?

My main issues post-total hysterectomy (four months ago) have been genitourinary so I feel for you. I've had two yeast infections and vaginal dryness. I've luckily not had a UTI yet but my bladder is frequently sore from IC/BPS. Prior to surgery, my bladder hurt terribly from endometriosis and adenomyosis so I went for two bladder instillation at my then gyno's office. I can say they helped with pain but have no idea if they work for UTIs. I'm curious to know anything about the Uromune vaccine so thank you for sharing it.

I use Uquora and I think it really helps. It’s probiotics and a packet that you mix with water to flush out your bladder. I was previously diagnosed with recurring UTIs, I had a hysterectomy 18 months ago and haven’t had any problems since other than one yeast infection. I swear by Uquora! You can order it online from their website.

Uromune vaccine-Studies from Europe show ~50–70% fewer UTIs, and some women become UTI-free for months to years. Uromune is NOT FDA-approved and not available in the U.S. as of now. It is available in some countries Spain, UK, Mexico, parts of Europe/LatAm.
Evidence is promising but based mostly on non-US studies; larger FDA-style trials are still lacking.

Have you considered or tried Estradiol cream applied to the urethra and vulva? It's very important and often overlooked. After hysterectomy low estrogen increases UTI risk.
Local estradiol keeps the vaginal & urethral tissue thick, elastic, and acidic, which, restores protective lactobacillus, and makes it harder for UTI bacteria to grow or attach. Large studies show ~50% reduction in recurrent UTIs with vaginal estrogen. It’s low-dose, local, and works where the problem is.
I had four UTIs between January and March 2025. Although I was already using vaginal estradiol twice a week, I didn’t notice a real difference until I began applying it nightly to the urethral area and vulva for a couple of months. Since April 2025, I’ve been UTI-free.
I had four UTIs between January and March 2025. Although I was already using vaginal estradiol twice a week, I didn’t notice a real difference until I began applying it nightly to the urethral area and vulva for a couple of months. Since April 2025, I’ve been UTI-free. If your UTI's are triggered by sex you can use a low dose Nitrofurantoin after sex to prevent a UTI. It's also used nightly for frequent UTIs not tied to sex. You are right to be concerned about continuous use of anti-biotic. Non-antibiotic options (D-mannose, methenamine