@jmfaith That's what I do. I started with 2x week and I found 3x week much better. No dryness at all anymore and I am 70 and I have never had a UTI, or any urinary issues. What we need to remember is that vaginal estradiol is not jus for our vaginas, but the cream also gets absorbed by our urinary/bladder area (not sure exactly how - but I do believe perhaps our vagina and bladder perhaps share a wall in there? 😀