I too have ET with Jak2, diagnosed in Oct 2022 at age 64. My platlet count hit in the 900’s, started with HU 500 one each day plus a 81 mg ASA for a month with a slight improvement showing with weekly blood tests. After 1 month moved to 2 pills every other day and weekly checks showed good improvement with a couple of Phlebotomy’s thrown in to bring the Hematocrit’s down.
I Tailored the meds to an ASA every morning with an HU 500 on Mon, Tues, Thurs, Fri and an HU 500 every night so 11 per week. I take my medication at 8:00am and 8:00pm each day, a 31 day am/pm pill organizer is a must for me as I take other meds as well.
My current platlet count is a steady 250/275 and Hematocrit count at 420.