@heyjoe415
Could you hotlink me to the Connect dealing with diclofenac gel.
I do see this on some research:
"Topical forms of diclofenac (solutions, gels, creams, patches) have been associated with only a low rate of serum enzyme elevations (generally less than 1%) that may be no greater than occurs with placebo or vehicle application. However, product labels for topical diclofenac mention the possibility of liver injury and several cases of clinically apparent liver injury attributed to topical diclofenac have been reported in the literature although the diagnosis in these cases have often been questionable. Thus, if clinically apparent liver injury due to topical forms of diclofenac occurs, it must be exceedingly rare."
https://www.ncbi.nlm.nih.gov/books/NBK547953/.
Ai overview:
Topical diclofenac generally causes low rates (under 1%) of liver enzyme elevations, similar to placebo, but clinically apparent liver injury from the gel is documented.
There are reported cases of acute liver injury linked to topical diclofenac, often resolving after stopping the gel, suggesting a possible connection.
The resoulution after stopping is important since most topical treatment is meant to be short term and not continued for any long period of time.