@lwools A great many should reply yes. The reason is that, even without the apixaban, the disorder is progressive. It tends to get worse over time for the great majority of patients. Sometimes it goes really bad inside of a few months and the heart suffers, and for others it takes years to develop into something that requires an intervention. You are a prime example of someone who took a drug and then found that his treated disorder was rapidly changing, and not for the better. This is just coincidence.