@heavyphil Regarding the first question —> If you recall that presentation by Dr. Rossi at the 2023 Mid-Year PCRI presentation: https://www.youtube.com/live/WTqPnSRYtW4

…at around timestamp 4:54:15 he’s asked a question (about re-radiation) where he responds, “…this gets to our unknowns; even though that normal tissue may not have been clinically damaged when you first treated it (with radiation), you may create some microscopic injury that may or may not be repaired. And we’re now just learning about how much of that is repaired as time goes by.”

They’re apparently still learning about that, what happens in the long term, and why.