@nafal, I'd like to welcome you to Connect, as well.
In addition to what @johnbishop has detailed, I did find some information about Cosentyx (Secukinumab) in our Bones, Joints & Muscles group that may interest you:
Older TNF Inhibitors Better for Psoriatic Arthritis: http://mayocl.in/2oLQRPj
And, you may also wish to read these posts about ALS (Lou Gehrig's disease) in the Brain & Nervous system group:
Mayo Clinic Breakthrough With ALS Treatment In Mice: http://mayocl.in/2pgp7ng
Finally — Some Hope for People With ALS: http://mayocl.in/2oLK9sx
Mayo Clinic researchers place ALS hope in stem cells: http://mayocl.in/2onnPTz
A while ago, @denver90 wrote about his sister who was diagnosed with ALS, and I hope will return with more insight for you.
@nafal, as John mentioned, have you talked with your healthcare team about Cosentyx, or considered getting a second opinion? I can only imagine the heartbreaking challenges with this condition; what symptoms are you dealing with, that you feel the drug is not working?
Sorry guy's i misspell one of my condition i have ankelsondelitis hope i spelled. It right not ALS. Sorry. Nafal