@marietter But if you have Chronic Kidney Disease, enough can cross into your system to possibly have an effect. Therefore with CKD it's suggested to limit to occasional use.

@marietter you need to be more specific regarding diclofenac as the oral formulation has a ton of side effects and drug interactions while the topical formulation does not. And since the topical formulation is 1% OTC and if used correctly as prescribed it has minimal systemic effects. Unfortunately many people do not read the literature or use the dosing rule found inside the package attached to the box.