@kik1 I saw my new specialist at Hollman Clinic, Launceston Hospital in Tasmania, she told me that Anagrelide was no longer available on the PBS and not recommended due to heart issues. I was not previously informed of problems by my haematologist, I was on it for many years and had no problems. I will be staying on the HU as it is helping to lower my platelets, slowly but steadily. Apparently Anagrelide works very fast to get them down, but is not good for the heart. Would have a good conversation with your doctor about Anagrelide.