As promised, my successful tapering off Effexor (Venlafaxine)

Posted by sheffieldsmith @sheffieldsmith, May 31, 2020

Below you will find the tapering plan that I used to successfully wean myself off Effexor (Venlafaxine). Feel free to share this with your doctor If you would like. I researched and came up with this plan, which was approved by my doctor, although she thought I could probably have weaned myself off sooner. But the reality is that we all have differing tolerance levels for tapering and weaning off this powerful drug from our bodies. Some people can taper faster, but usually not those who have been on this drug for years (like myself, since October 2002). I tapered off EffexorXR 150mg capsules about 5 years ago down to 75mg, and was on that maintenance dosage for a couple of years until I started weaning off the 75mg a year ago in April 2019. As of October, 2029, I’ve been withdrawal symptom free, but I still have occasional periods of anxiety when triggered. But I realize these waves of anxiety will soon pass, and I cope by deep breathing, taking a walk, having a cup of chamomile tea, etc. Cutting my exposure to watching upsetting news has really helped a lot as well. These days I seek things that bring joy and peace in such a turbulent world. Wishing you all a successful weaning off this powerful drug.

Weaning off Venlafaxine XR 75mg (Effexor-(extended release)capsules:
Weaning plan off plan that worked for BSS:
1. Inform your doctor you are tapering down from 75 mg Venlafaxine and ask them to prescribe 37.50 tabs to help with tapering doses (1/2 dosage down from 75 mg Venlafaxine capsules). The tabs are easier to cut into halves and quarter dosages than counting out beads from the capsules.
2. Begin your taper only after you are on a non-withdrawal symptomatic dosage level. If you were having w/d symptoms at 75 mg, you’ll need to go back to the level at which you were symptomless and stay there for 2-3 weeks before deceasing to a slow taper. NOTE: after successfully tapering from 150mg Venlafaxine down to 75mg for a month, I was unable to tolerate a drop cold turkey from a daily dosage of 75mg down to 37.50mg (50%) without having bothersome withdrawal symptoms of dizziness, brain fog, brain zaps, and nausea. So after researching various tapering plans, I came up with a slower tapering schedule my body could tolerate to finish the tapering from 75mg to 37.50mg, and then on to complete the tapering. Your body may even need slower tapering, so adjust according.
3. Week 1-2: Take 75mg caps MWFSu; take 37.50mg tab on alternate days Tu,Th, Sa. At the end of week 2, if you only have relatively mild to no withdrawal symptoms, proceed to week 3. IMPORTANT: If you have intolerable symptoms, adjust to a slower tapering schedule by adding an additional 1/2 tab on the alternate days (or take a total of one and a half 37.50 tabs on alternate days). You’ll then have to tweak the rest of your tapering schedule. If all goes well, proceed with week 3.
4. Week 3-4: Cut a few 37.50 tabs in half with a pill cutter or exacto knife blade to create quarter pieces. Take 37.50mg tab on MWFSu and take 3/4 tab on alternate days Tu, Th, Sa.
5. Week 5-6: Take 3/4 of a tab MWFSu, and take 1/2 tab on alternate days Tu, Th, Sa. If only mild symptoms, proceed to week 5.
6. Week 7-8: Take 1/2 tab on MWFSu; and take 1/4 tab on alternate days Tu, Th, Sa. If no symptoms, continue to week 7.
7. Week 9-10: Take 1/4 tab on MWFSu; and take 1/8 tab (cut 1/4 tabs in half) on alternate days Tu, Th, Sa. *Notice the quartering of doses into crumbs now...very important to keep small dosage tapering to remain withdrawal symptom free.
8. Week 11-12: Take 1/8 tab crumb on MWFSu; take none on alternate days Tu, Th, Sa. *If skipping alternate days produces symptoms, stay on 1/8 tab crumbs for a couple of weeks before alternating skip days for a couple of weeks.
You’ll find that this schedule may have to be tweaked for you by extending the time you stay on a taper...possibly up to 3-4 weeks before beginning a new tapering down. It all depends on how you tolerate the first two weeks.

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Profile picture for sears @sears

Effexor doesn't come in liquid form?

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@sears
Yes it does with a siringe that fits in the cap of the liquid bottle and you turn the bottle upside down and draw the liquid into the siringe. It doesn't leak.
It is easier to taper the medicine that way and that's what I got it for.

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Profile picture for michelle73 @michelle73

@sears
Yes it does with a siringe that fits in the cap of the liquid bottle and you turn the bottle upside down and draw the liquid into the siringe. It doesn't leak.
It is easier to taper the medicine that way and that's what I got it for.

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@michelle73 I don’t know why doctors don’t use the liquid more. Much easier than messing with beads.

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Profile picture for goodheartmom @goodheartmom

@goodheartmom
he has been on this medication since August 2025, 4 months ago he started taking this.
Venlafaxine ER 37.5 (2) capsules

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@goodheartmom Since he has been taking the drug for months and not years, his prospects of discontinuing successfully are better. Generally, the lower the dose and the less time on the drug, the lesser the side effects from withdrawal. That said, everyone is different and your husband has other issues, possibly other medications?
There is a tremendous amount of information on this website--yes, it would take a long time to read it all; you would learn a lot in the process and might be able to work out a solution for yourself. Another excellent resource is The Maudsley Deprescribing Guidelines, a book published 2024 by Mark Horowitz and David Taylor. Mark Horowitz/Outro has a lot of information online to aid one in discontinuing this drug successfully.
I would suggest you speak with your pharmacist. Effexor is available in 37.5 mg capsules (extended release, taken once a day), and in 25 mg tablets (immediate release, taken twice a day). My independent pharmacist was able to create a liquid form which I take twice a day and is simple to reduce over time. It is possible, albeit tedious, to open the capsules and reduce the contents by a fraction. My pharmacist helped me learn how to do this and provided empty capsules, a tiny lipped tray and a funnel for refilling capsules. It is also possible to use a pill cutter to cut the tablets into reduced doses over time. An independent pharmacist could create a liquid for you, but compounds are not typically covered by insurance.
Learn as much as you can and create a reduction schedule that best works for you and your husband. If you find that he is decreasing too quickly, then you simply up the dose, whether partially or fully. The main issue I see here is that symptoms of withdrawal (nightmares is one) might mimic your husband's side effects from the drug, and I do not know how you would distinguish between the two.
My heart goes out to you. I am so sorry that you find yourselves in this difficult position--but you CAN do it.

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Profile picture for cjf @cjf

I tapered from effexor 187.5 mg by my doctor in 4 weeks and my life has been hell. I am 84 years old - a widow for 20 years and have a lot of issues in that time. Years earlier my physician prescribed zoloft. It worked well and 3 was weaned off it by my doctor in a relatively short time without having any problems. I think my doctor prescribed effexor due to my age. What a tragedy this drug has made of my life. Why aren't using your plan. It seems sounder & safer than the plan my doctor used. I no longer want him to treat me. I would love to send him your way of tapering. I will not use your name unless I have your permission. Thanks and God bless.

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@cjf I sincerely hope you sent my tapering plan off Effexor to your doctor. He obviously wanted to keep you on it as prescriptions are a cash cow and steady income. So he may not give any creedance to a successful weaning off plan, unless he is truly all about supporting your complete healing from taking the most addictive antianxiety/anti depressive in the market. And I think we all know the answer to that question. I was a lucky one who had the support of my Doctor, who offered a plan that tapered too early for me and I had to figure out my own slower “crumb” dosing. I pray you were successful in your deliverance from this evil drug! 🙏💕🙏🙌

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Profile picture for intendtorecover @intendtorecover

It might be difficult, but get off now before you risk, what some studies are showing could be permanent damage.
You'll be sick, but you'll get over it.
I used this drug for ten years for treatment of pain. It's been almost a year and I now suffer from anxiety and depression. I've found out since that the recommended length of using an antidepressant is a year or two!

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@intendtorecover buspirone 10mg helped me deal with the depression and anxiety and I only needed it a short time to take off the edge from overthinking. It is not addictive and helps greatly. I only take it as needed on occasion, but no longer 3 times a day.

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Profile picture for jules61 @jules61

Has anyone GAINED weight after stopping EFFEXOR?

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@jules61 I did not gain weight. I actually lost it as I was doing intermittent fasting already due to my late night owl researching of natural remedies.

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Profile picture for effexcausinganxiety @effexcausinganxiety

I am 73 yo female and have been on Effexor for 22 years at 150 mgs. It is causing anxiety during winter months. I have surges and it is connected to my GI track. It makes mr ainsey I am going to start a long titrate like Sheffield Smith. Will take time to get to 75 mgs -. I went on the stuff in 2000 because of mild anxiety and it had an off label use for reducing hot flashes. I was a breast cancer patient show they would not give me any estrogen. During the inter months this stuff literally sets my "ass on fire". I think it should be taken off the market. Please share any experience strength and hope you can.

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@effexcausinganxiety I pray your efforts were most successful and you were able to wean yourself off that demonic, addictive drug! 🙏💕🙏🥰🙌

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Profile picture for sears @sears

@michelle73 I don’t know why doctors don’t use the liquid more. Much easier than messing with beads.

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@sears
Yes I actually live in Italy but I got the idea from watching The psychiatrist who works for a psychiatric drug tapering clinic.
I finally got a woman doctor that was more open minded and she prescrived the liquid drug for me in liquid form

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Profile picture for michelle73 @michelle73

@sears
Yes I actually live in Italy but I got the idea from watching The psychiatrist who works for a psychiatric drug tapering clinic.
I finally got a woman doctor that was more open minded and she prescrived the liquid drug for me in liquid form

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@michelle73 I used liquid Valium when tapering off of Xanax. Made the process much easier. Was it Josef Witt-Doering?

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My apologies for the error regarding October 2029 when I was symptom free from tapering off Venlafaxine (Effexor). The time period should have been October 2019.

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