@nancyra Hi, I am currently on HU, hoping when I see my new haematologist tomorrow, they put me back on Anagrelide. Was on Anagrelide for over 16 years with no problems. On HU for 1 year, my hair has thinned out badly and i am just so tired all of the time. While on Anagrelide I did not have any side affects. Fingers crossed.