Connect
← Return to What are my chances that MGUS turns into multiple myeloma?
Discussion
What are my chances that MGUS turns into multiple myeloma?
Blood Cancers & Disorders | Last Active: Feb 5 11:30am | Replies (42)Comment receiving replies
I believe 1% of MGUS patients progress to full-blown MM. It's a rare malady to begin with. It occurs in only .5% of the population, more so in Blacks, for some reason. If you can get through the first five years of SMM, the chances of it progressing to MM go down. There's a lot of information on the Multiple Myeloma Research Foundation website and, of course, Dr. Google.
Replies to "I believe 1% of MGUS patients progress to full-blown MM. It's a rare malady to begin..."
Sorry, but what is SMM?
Connect
@rimord and @redvrm yes, although there are different classifications of MGUS with different risk stratification. Then age and coexisting conditions are also a consideration.
The best person to consult about this is your hematologist/oncologist.
But…
“The three major risk factors for the progression of MGUS are an abnormal serum FLC ratio (i.e., the ratio of free immunoglobulin κ to λ light chains in the serum), non-IgG MGUS, and a high serum M protein level (≥1.5 g/dL) (Figure 1)11,43. Based on the Mayo Clinic’s stratification model, the presence of all three factors constitutes high-risk MGUS. High-intermediate-risk MGUS is present if any two of the factors are present, low-intermediate-risk MGUS is present if any one of the three factors is present, and the absence of all three factors is classified as low-risk MGUS. The risk of progression to LPM at 20 years when one, two, and three risk factors are present is 5%, 21%, and 58%, respectively.”
From the publication below, based on Mayo Clinic’s risk stratification methodology.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9720897/
Will you let me know how this goes for you?