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@welchllb I have been on LDN (max 4mg, 3.5 at present. I didn't think it was helping as I still had inflammation and pain. Until i went off of it and pain etc got do much worse. I almost missed the fact that it was worse perhaps because I went off of it. I try to pay so little attention to my body, I kind of forgot to notice? Do you get that? Chronic pain (CRPS for one for me) makes me try to stay separate from my body. I suddenly remembered I had gone off ldn 3 months previous. I didn't know it was helping till I stopped taking it. Depending on how long you stay off, you may need to start at a lower dose again? Best of luck.