I do not have arthritis and have had many years of Prolia until I had an unexpected adverse reaction. The pain was unbearable in ankles all the way up one leg. We couldnt find the culprit so as I was first getting better went for six mos shot! Double severe pain in both ankles, legs, hair loss and rash. Now I can barely walk. Nothing seems to take down pain. Swelling seems to be entire foot calves all the way up to femur. Lighting pain at times. Pain 24 hrs a day going on 4th week. I have had many tests. This is not sciatica!